Publications

  1. Valadkhan, S. (2011) A SnRNP's Ordered Path to Maturity. Genes & Development 25.15 : 1563-567. View PDF. View comments
  2. Jaladat Y, Zhang B, Mohammadi A, Valadkhan, S. (2011) Splicing of an intervening sequence by protein-free human snRNAs. RNA Biology 8:3. View PDF. View comments.
  3. Lee C, Jaladat Y, Mohammadi A, Sharifi A, Geisler S, Valadkhan S. (2010) Metal Binding and Substrate Positioning by Evolutionarily Invariant U6 Sequences in Catalytically Active Protein-free SnRNAs. Rna 16.11:2226-238. View PDF. View comments.
  4. Jaladat Y, Valadkhan S. (2010) The spliceosomal proteome: At the heart of the largest cellular ribonucleoprotein machine. Proteomics 10:4128-4141. View PDF. View comments.
  5. Valadkhan S. (2010) Role of the SnRNAs in Spliceosomal Active Site. RNA Biology 7.3: 345-53. View PDF. View comments.
  6. Valadkhan S, Nilsen TW. (2010) Reprogramming of the non-coding transcriptome during brain development J.Biol. View PDF. View comments.
  7. Valadkhan S, Mohammadi A, Jaladat Y, Geisler S. (2009) Protein-free small nuclear RNAs catalyze a two-step splicing reaction. Proc Natl Acad Sci U S A. 106: 11901-11906. and supplementary data. View PDF. View comments.
  8. Valadkhan S., Manley JL. (2009) The use of simple model systems to study spliceosomal catalysis.RNA.15:4-7. View PDF. View comments.
  9. Valadkhan S., Mohammadi A., Wachtel C., Manley J.L. (2007) Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. RNA. 13:2300-11. View PDF. View comments.
  10. Valadkhan S. (2007) The spliceosome: caught in a web of shifting interactions. Curr. Opin. Struct. Biol.17:310-5. View PDF. View comments.
  11. Valadkhan S. (2007) The spliceosome: a ribozyme at heart? Biol. Chem. 388:693-697. View PDF. View comments.
  12. Valadkhan S. (2005) snRNAs as the catalysts of pre-mRNA splicing. Curr. Opin. Chem. Biol. 9:603-608. View PDF. View comments.
  13. Valadkhan S. (2005) Young Scientist Award essay winner. Construction of a minimal, protein-free spliceosome. Science 307:863-864. View PDF. View comments.
  14. Valadkhan S., Manley JL. (2003) Characterization of the catalytic activity of U2 and U6 snRNAs. RNA 9:892-904. View PDF. View comments.
  15. Valadkhan S., Manley JL. (2002) Intrinsic metal binding by a spliceosomal RNA. Nat. Struct. Biol. 9:498-499. View PDF. View comments.
  16. Valadkhan S., Manley JL. (2001) Splicing-related catalysis by protein-free snRNAs. Nature 413:701-707. View PDF. View comments.
  17. Valadkhan S., Manley JL. (2000) A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. RNA 6:206-219. View PDF. View comments.
  18. Sun JS, Valadkhan S., Manley JL. (1998) A UV-crosslinkable interaction in human U6 snRNA. RNA 4:489-497. View PDF. View comments.