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Publications

Valadkhan S., Mohammadi A., Wachtel C., Manley J.L. (2007) Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. RNA. 13:2300-11.pdf

Valadkhan S. (2007) The spliceosome: caught in a web of shifting interactions. Curr. Opin. Struct. Biol.17:310-5pdf

Valadkhan S. (2007) The spliceosome: a ribozyme at heart? Biol. Chem. 388:693-697. pdf

Valadkhan S. (2005) snRNAs as the catalysts of pre-mRNA splicing. Curr. Opin. Chem. Biol. 9:603-608. pdf

Valadkhan S. (2005) Young Scientist Award essay winner. Construction of a minimal, protein-free spliceosome. Science 307:863-864. pdf

Valadkhan S., Manley JL. (2003) Characterization of the catalytic activity of U2 and U6 snRNAs. RNA 9:892-904.pdf

Valadkhan S., Manley JL. (2002) Intrinsic metal binding by a spliceosomal RNA. Nat. Struct. Biol. 9:498-499. pdf

Valadkhan S., Manley JL. (2001) Splicing-related catalysis by protein-free snRNAs. Nature 413:701-707. pdf

Valadkhan S., Manley JL. (2000) A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. RNA 6:206-219. pdf

Sun JS, Valadkhan S., Manley JL. (1998) A UV-crosslinkable interaction in human U6 snRNA. RNA 4:489-497. pdf

Valadkhan Lab is located in the Center for Molecular Biology, Case Western Reserve University,  
10900 Euclid Avenue, Wood RT 100-8, Cleveland, OH 44106-4973. Phone: (216) 368-1068. Fax: (216) 368-2010
 
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  Last updated April 8, 2008