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News


August 2011: Bing Zhang received a COF Scholarship form the State of Ohio for academic excellence.

June 2011: Saba chaired a session on RNA synthetic biology in the 16th annual meeting of the RNA Society, which was held in Kyoto, Japan.

May 2011: Saba's PhD advisor, Dr. James L. Manley, was elected to the National Academy of Sciences.

October 2010: Saba organized the 2010 Regional RNA Meeting of the MidWest (RRM) together with David Rueda.

October 2009: Saba and David Rueda were the co-chairs for the 2009 Regioal RNA Meeting of the MidWest (RRM).

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Publications

Valadkhan, S. (2011) A SnRNP's Ordered Path to Maturity. Genes & Development 25.15 : 1563-567. pdf version
Jaladat Y, Zhang B, Mohammadi A, Valadkhan, S. (2011) Splicing of an intervening sequence by protein-free human snRNAs. RNA Biology 8:3. pdf version
Lee C, Jaladat Y, Mohammadi A, Sharifi A, Geisler S, Valadkhan S.(2010) Metal Binding and Substrate Positioning by evolutionarily invariant U6 sequences.... pdf version
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Research


Valadkhan lab is interested in the role of non-protein-coding RNA molecules in higher eukaryotes, especially in human. It has been recently shown that ~99% of the RNAs transcribed from the human genome do not code for proteins, but function as long untranslated RNA molecules. This intriguing discovery will have a huge impact on the way we think about cellular function. It is becoming increasingly evident that these long non-protein-coding RNAs (lncRNAs) are playing highly critical roles in the cell, and recent data suggests that they form highly complex regulatory pathways that have made the enormous complexity of human body possible. In fact, there are some reports that suggest that these RNAs are responsible for us, humans, being different from other primates! Our research focuses on the function of this class of RNAs in cellular differentiation and homeostasis, with particular emphasis on neurogenesis and cancer.
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